OVARIAN IMMATURE (MALIGNANT) TERATOMA
Keywords:
Immature ovarian teratoma, paraneoplastic encephalitis, OCT4, fertility-preserving surgery.Abstract
The immature teratoma was first described in 1960 and cay be pure or mixed with a mature component. It is the second most common malignant germ cell neoplasm of all ovarian cancers (representing <1%). About 50% of pure immature teratomas of the ovary occur in women between the ages of 10 and 20 years. Treatment should be considered to preserve future fertility because the majority of ovarian germ cell tumors are curable with conservative surgery and combined combination chemotherapy. Most patients diagnosed with an immature teratoma are cured of their disease. However, in all patients, we recommend close follow-up, particularly in the first 2 years after diagnosis, where there is a greater chance of recurrence.
References
2. Soledad Jorge, Nathaniel L. Jones, Ling Chen, June Y. Hou, Ana I. Tergas, William M. Burke, Cande V. Ananth, Alfred I. Neugut, Dawn L. Herhshman, Jason D.Wright . Characteristics, treatment and outcomes of women with immature ovarian teratoma, 1998–2012 Gynecologic Oncology (2016).
3. Nathalie Douay-Hauser1, Martin Koskas1, Francine Walker2, Dominique Luton1 and Chadi Yazbeck. Diagnosis and management of an immature teratoma during ovarian stimulation: a case report. Journal of Medical Case Reports 2011, 5:540.
4. Kim MJ, Kim NY, Lee D-Y, et al. Clinical characteristics of ovarian teratoma: agefocused retrospective analysis of 580 cases. Am J Obstet Gynecol 2011;205:32.e1-4.
5. Anne M. van Altena, Geertruida J. Wijnberg, Eva Kolwijck, Joanne A. de Hullu, Leon F.A.G. A patient with bilateral immature ovarian teratoma presenting with paraneoplastic encephalitis. Gynecologic Oncology 108 (2008) 445–448.
6. Pallavi V. Reddihalli, Anbukkani Subbian, K. Umadevi, Praveen S. Rathod, Shobha Krishnappa, Shakuntala P. Nanaiah, Uttam D. Bafna. Immature teratoma of ovary outcome following primary and secondary surgery: study of a single institution cohort. European Journal of Obstetrics & Gynecology and Reproductive Biology 192 (2015) 17–21.
7. Irene Perelson , Elisa García, Pluvio Coronado Martín, Miguel Ángel Herraiz, José Vidart. Immature ovarian teratoma in pregnancy Prog Obstet Ginecol. 2009;52(5):307-11.
8. Sánchez Andrés, Valdés Diéguez, Marco Macián y CarrascoMoreno. Teratoma inmaduro de ovario y miocardiopatía dilatada An Pediatr(Barc).2010;73(6):347–351.
9. Adnan Aydiner,Hakan Gurvit and Isin Baral. Paraneoplastic limbic encephalitis with immature ovarian teratoma. Journal of Neuro-Oncology 37: 63–66, 1998.
10. A Kurata, K Hirano, M Nagane and Y Fujioka. Immature Teratoma of the Ovary With Distant Metastases: Favorable Prognosis and Insights Into Chemotherapeutic Retroconversion. International Journal of Gynecological Pathology, 2010 Sep; 29(5):438-44.
11. S Choudhary, N Fasih, M Mc Innes and C Marginean. Imaging of ovarian teratomas: Appearances and complications. Journal of Medical Imaging and Radiation Oncology 53 (2009) 480–488.
12. Chia-Hui Chen, Ming-Jie Yang, Ming-Huei Cheng, Ming-Shyen Yen, Chiung-Ru Lai, Peng-Hui Wang. Fertility Preservation with Treatment of Immature Teratoma of the Ovary. J Chin Med Assoc 2007;70(5):218–221.
13. Olivia L Snir, Maura DeJoseph, Serena Wong, Natalia Buza and Pei Hui. Frequent homozygosity in both mature and immature ovarian teratomas: a shared genetic basis of tumorigenesis. Modern Pathology (2017), 1–9.
14. Danielle Vicus, Mario E. Beiner, Blaise Clarke, Shany Klachook, Lisa W. Le, Stephane Laframboise, Helen Mackay. Ovarian immature teratoma: Treatment and outcome in a single institutional cohort. Gynecologic Oncology 123 (2011) 50–53.
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