Phyllodes tumor: literature review
Keywords:
Phyllodes tumor, breast neoplasms, surgery Source: DeCS (Descriptors in Health Sciences)Abstract
Phyllodes tumor of the breast is a rare, but clinically important fibroepithelial tumor, accounting for <1% of breast tumors. Histologically, phyllodes tumor is classified into three; as: benign, borderline or malignant, based on a combination of histological and pathological criteria. This classification of the phyllodes breast tumor is precisely relevant in the clinic. While local recurrence of phyllodes tumor may occur in all grades, metastasis is mostly limited to malignant and few borderline cases, usually the latter two types having a worse prognosis of the disease. Treatment is mainly surgical as phyllodes tumor doesn´t respond well to systemic therapy. This review of the phyllodes tumor allows to guide the entire medical community based on the most recent evidence to diagnose and thus be able to manage this pathology, avoiding its complications.
References
1. Torres Aja L, Caballero Aja N, Puerto Lorenzo J. Tumor phyllodes benigno de la mama. Revisión de la literatura y presentación de un caso. Revista Finlay. 2017;7(4):290-293.
2. Bumpers H, Tadros T, Gabram-Mendola S, Rizzo M, Martin M, Zaremba N et al. Phyllodes tumors in African American women. The American Journal of Surgery. 2015;210(1):74-79.
3. Corso D, Contreras D, Javier Á, Guzmán L, Díaz S, García O et al. Tumor filoide. Estado del arte. Revista Colombiana de Cancerología. 2016;20(2):79-86.
4. de Valle Corredor C, Fernández Muñoz L, Martínez Gómez E, Cajal Lostao R, Ramos Guillén P, García Pineda V et al. Tumor filodes maligno: a propósito de un caso y revisión de la literatura. Clínica e Investigación en Ginecología y Obstetricia. 2014;41(4):179-182.
5. Makhija D, Shah H, Bothra J, Jayaswal S. An adolescent with a phyllodes tumor: A case report and review. International Journal of Pediatrics and Adolescent Medicine. 2016;3(4):180-183.
6. Amir R, Rabah R, Sheikh S. Malignant Phyllodes Tumor of the Breast with Metastasis to the Pancreas: A Case Report and Review of Literature. Case Reports in Oncological Medicine. 2018;2018(6491675):1-5.
7. Morante Z, Araujo J, Fuentes H, Neciosup S, Mas L, Gomez H. Tumor filoides de la mama, características y pronóstico en una cohorte retrospectiva con 7 años de seguimiento. Carcinos. 2015;5(1):10-19.
8. Schultzel M, Kalsi R, Goldman F. Fungating malignant phyllodes tumor. Cancer Treatment Communications. 2014;2(2-3):30-33.
9. Jimenez J, Marquez G, Olaya E, Gomez D, Arteaga A. Tumor phyllodes. Perinatología y Reproducción Humana. 2013;27(2):106-112.
10. Demian G, Fayaz S, El-Sayed Eissa H, Nazmy N, Samir S, George T et al. Phyllodes tumors of the breast: Analysis of 35 cases from a single institution. Journal of the Egyptian National Cancer Institute. 2016;28(4):243-248.
11. Zhang Y, Kleer C. Phyllodes Tumor of the Breast: Histopathologic Features, Differential Diagnosis, and Molecular/Genetic Updates. Archives of Pathology & Laboratory Medicine. 2016;140(7):665-671.
12. Jiménez-Ibáñez LC, Soberano-Almeida JG, García-Padrón OA. Evolución natural del tumor filodes de mama. Reporte de un caso. Ginecol Obstet Mex. 2018 agosto;86(8): 548-553.DOI:
https://doi.org/10.24245/gom.v86i8.1479
13. Tan B, Acs G, Apple S, Badve S, Bleiweiss I, Brogi E et al. Phyllodes tumours of the breast: a consensus review. Histopathology. 2015;68(1):5-21.
14. Melo-Uribe M, Cajiao G, Valenzuela N, Cajiao V, Parra-Medina R. Tumor filoide en una mujer indígena colombiana. Repertorio de Medicina y Cirugía. 2016;25(3):178-182.
15. Ruiz L, Ebuoma L, Benveniste M, Nagi C, Ortiz T, Benveniste A. Case Report: Metastatic Phyllodes Tumor. Seminars in Ultrasound, CT and MRI. 2018;39(1):122-126.
16. Leraas H, Rosenberger L, Ren Y, Ezekian B, Nag U, Reed C et al. Pediatric phyllodes tumors: A review of the National Cancer Data Base and adherence to NCCN guidelines for phyllodes tumor treatment. Journal of Pediatric Surgery. 2018;53(6):1123-1128.
17. Mylvaganam S, Toro C, Frank L, Vestey S, Thrush S. Phylloides tumours of the breast: best practice for follow-up. Updates in Surgery. 2015;67(1):91-95.
18. Ouyang Q, Li S, Tan C, et al. Benign Phyllodes Tumor of the Breast Diagnosed After Ultrasound-Guided Vacuum-Assisted Biopsy: Surgical Excision or Wait-and-Watch? Ann Surg Oncol 2016; 23:1129.
19. Lu Y, Chen Y, Zhu L, et al. Local Recurrence of Benign, Borderline, and Malignant Phyllodes Tumors of the Breast: A Systematic Review and Meta-analysis. Ann Surg Oncol 2019; 26:1263.
20. Moo TA, Alabdulkareem H, Tam A, et al. Association Between Recurrence and Re-Excision for Close and Positive Margins Versus Observation in Patients with Benign Phyllodes Tumors. Ann Surg Oncol 2017; 24:3088.
21. Cowan ML, Argani P, Cimino-Mathews A. Benign and low-grade fibroepithelial neoplasms of the breast have low recurrence rate after positive surgical margins. Mod Pathol 2016; 29:259.
22. Onkendi EO, Jimenez RE, Spears GM, et al. Surgical treatment of borderline and malignant phyllodes tumors: the effect of the extent of resection and tumor characteristics on patient outcome. Ann Surg Oncol 2014; 21:3304.
23. Shah-Patel L. Malignant phyllodes breast tumor. Radiology Case Reports. 2017;12(4):645-647.
24. Roberts N, Runk D. Aggressive malignant phyllodes tumor. International Journal of Surgery Case Reports. 2015; 8:161-165.
25. Wang Q, Su J, Lei Y. Recurrent malignant phyllodes tumor of the breast. Medicine. 2017;96(49): e9069.
26. Câmara S, Gonzàlez-Farré X, Vargas-Moniz J. Giant phyllodes tumour – Case report, oncoplastic treatment and literature controversies. Revista de Senología y Patología Mamaria. 2017;30(2):79-84.
27. Ditsatham C, Chongruksut W. Phyllodes tumor of the breast: diagnosis, management and outcome during a 10-year experiencep. Cancer Management and Research. 2019; 11:7805-7811.
28. National Comprehensive Cancer Network (NCCN). NCCN Clinical practice guidelines in oncology (NCCN Guidelines). Soft Tissue Sarcoma. Version 2.2016. www.nccn.org
29. Amer A, Ainley P, Thompson R, Mathers H. Postoperative follow-up practice of phyllodes tumour in the UK: Results from a national survey. The Surgeon. 2018;16(2):74-81.
2. Bumpers H, Tadros T, Gabram-Mendola S, Rizzo M, Martin M, Zaremba N et al. Phyllodes tumors in African American women. The American Journal of Surgery. 2015;210(1):74-79.
3. Corso D, Contreras D, Javier Á, Guzmán L, Díaz S, García O et al. Tumor filoide. Estado del arte. Revista Colombiana de Cancerología. 2016;20(2):79-86.
4. de Valle Corredor C, Fernández Muñoz L, Martínez Gómez E, Cajal Lostao R, Ramos Guillén P, García Pineda V et al. Tumor filodes maligno: a propósito de un caso y revisión de la literatura. Clínica e Investigación en Ginecología y Obstetricia. 2014;41(4):179-182.
5. Makhija D, Shah H, Bothra J, Jayaswal S. An adolescent with a phyllodes tumor: A case report and review. International Journal of Pediatrics and Adolescent Medicine. 2016;3(4):180-183.
6. Amir R, Rabah R, Sheikh S. Malignant Phyllodes Tumor of the Breast with Metastasis to the Pancreas: A Case Report and Review of Literature. Case Reports in Oncological Medicine. 2018;2018(6491675):1-5.
7. Morante Z, Araujo J, Fuentes H, Neciosup S, Mas L, Gomez H. Tumor filoides de la mama, características y pronóstico en una cohorte retrospectiva con 7 años de seguimiento. Carcinos. 2015;5(1):10-19.
8. Schultzel M, Kalsi R, Goldman F. Fungating malignant phyllodes tumor. Cancer Treatment Communications. 2014;2(2-3):30-33.
9. Jimenez J, Marquez G, Olaya E, Gomez D, Arteaga A. Tumor phyllodes. Perinatología y Reproducción Humana. 2013;27(2):106-112.
10. Demian G, Fayaz S, El-Sayed Eissa H, Nazmy N, Samir S, George T et al. Phyllodes tumors of the breast: Analysis of 35 cases from a single institution. Journal of the Egyptian National Cancer Institute. 2016;28(4):243-248.
11. Zhang Y, Kleer C. Phyllodes Tumor of the Breast: Histopathologic Features, Differential Diagnosis, and Molecular/Genetic Updates. Archives of Pathology & Laboratory Medicine. 2016;140(7):665-671.
12. Jiménez-Ibáñez LC, Soberano-Almeida JG, García-Padrón OA. Evolución natural del tumor filodes de mama. Reporte de un caso. Ginecol Obstet Mex. 2018 agosto;86(8): 548-553.DOI:
https://doi.org/10.24245/gom.v86i8.1479
13. Tan B, Acs G, Apple S, Badve S, Bleiweiss I, Brogi E et al. Phyllodes tumours of the breast: a consensus review. Histopathology. 2015;68(1):5-21.
14. Melo-Uribe M, Cajiao G, Valenzuela N, Cajiao V, Parra-Medina R. Tumor filoide en una mujer indígena colombiana. Repertorio de Medicina y Cirugía. 2016;25(3):178-182.
15. Ruiz L, Ebuoma L, Benveniste M, Nagi C, Ortiz T, Benveniste A. Case Report: Metastatic Phyllodes Tumor. Seminars in Ultrasound, CT and MRI. 2018;39(1):122-126.
16. Leraas H, Rosenberger L, Ren Y, Ezekian B, Nag U, Reed C et al. Pediatric phyllodes tumors: A review of the National Cancer Data Base and adherence to NCCN guidelines for phyllodes tumor treatment. Journal of Pediatric Surgery. 2018;53(6):1123-1128.
17. Mylvaganam S, Toro C, Frank L, Vestey S, Thrush S. Phylloides tumours of the breast: best practice for follow-up. Updates in Surgery. 2015;67(1):91-95.
18. Ouyang Q, Li S, Tan C, et al. Benign Phyllodes Tumor of the Breast Diagnosed After Ultrasound-Guided Vacuum-Assisted Biopsy: Surgical Excision or Wait-and-Watch? Ann Surg Oncol 2016; 23:1129.
19. Lu Y, Chen Y, Zhu L, et al. Local Recurrence of Benign, Borderline, and Malignant Phyllodes Tumors of the Breast: A Systematic Review and Meta-analysis. Ann Surg Oncol 2019; 26:1263.
20. Moo TA, Alabdulkareem H, Tam A, et al. Association Between Recurrence and Re-Excision for Close and Positive Margins Versus Observation in Patients with Benign Phyllodes Tumors. Ann Surg Oncol 2017; 24:3088.
21. Cowan ML, Argani P, Cimino-Mathews A. Benign and low-grade fibroepithelial neoplasms of the breast have low recurrence rate after positive surgical margins. Mod Pathol 2016; 29:259.
22. Onkendi EO, Jimenez RE, Spears GM, et al. Surgical treatment of borderline and malignant phyllodes tumors: the effect of the extent of resection and tumor characteristics on patient outcome. Ann Surg Oncol 2014; 21:3304.
23. Shah-Patel L. Malignant phyllodes breast tumor. Radiology Case Reports. 2017;12(4):645-647.
24. Roberts N, Runk D. Aggressive malignant phyllodes tumor. International Journal of Surgery Case Reports. 2015; 8:161-165.
25. Wang Q, Su J, Lei Y. Recurrent malignant phyllodes tumor of the breast. Medicine. 2017;96(49): e9069.
26. Câmara S, Gonzàlez-Farré X, Vargas-Moniz J. Giant phyllodes tumour – Case report, oncoplastic treatment and literature controversies. Revista de Senología y Patología Mamaria. 2017;30(2):79-84.
27. Ditsatham C, Chongruksut W. Phyllodes tumor of the breast: diagnosis, management and outcome during a 10-year experiencep. Cancer Management and Research. 2019; 11:7805-7811.
28. National Comprehensive Cancer Network (NCCN). NCCN Clinical practice guidelines in oncology (NCCN Guidelines). Soft Tissue Sarcoma. Version 2.2016. www.nccn.org
29. Amer A, Ainley P, Thompson R, Mathers H. Postoperative follow-up practice of phyllodes tumour in the UK: Results from a national survey. The Surgeon. 2018;16(2):74-81.
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2020-11-17
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Literature review
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Phyllodes tumor: literature review. (2020). Medicina Legal De Costa Rica, 37(1). https://www.binasss.sa.cr/ojssalud/index.php/mlcr/article/view/158
