Poisoning with long-lasting anticoagulant rodenticides
Keywords:
Rodenticide, anticoagulation, intoxicationAbstract
Rodenticides are agriculturally and domestically used substances used for the control of rats and other rodents, easily available on the market. Anticoagulant rodenticides have a similar mechanism of action than that of warfarin, but their potency is bigger. The spectrum of clinical manifestations of rodenticide intoxications is broad; and it varies from asymptomatic cases to hemorrhages that compromise the patient’s life. Treatment is based on active bleeding control and reposition of its logical antidote Vitamin K in order to restore hemostasis.
References
2. Yan, H., Zhu, L., Zhuo, X., Shen, M., y Xiang, P. (2016). Anticoagulant rodenticide intoxication in east China: a three-year analysis. Forensic Sciences Research, 1(1), 22-27.
3. Chey, H., y Buchanan, S. (2008). Toxins in everyday life. Primary Care Clinical Office Practice, 35, 707-727.
4. King, N. & Tran, M. (2015). Long-Acting Anticoagulant Rodenticide (Superwarfarin) Poisoning: A Review of Its Historical Development, Epidemiology, and Clinical Management. Transfusion Medicine Reviews, 29, 250-258.
5. Beriain-Rodriguez, M., Gómez-Cortés, B., Benito-Fernández, J., y Mintegi-Raso, S. (2008). Ingesta accidental de superwarfarinas. An Pediatr (Barc), 68(5): 503-506.
6. Yu, H., Lin, J., Fen, J., Lin, J., Liu, S., Weng, C., et al. (2013). Outcomes of patients with rodenticide poisoning at a far east poison center. SpringerPlus, 2, 505-511.
7. Centro Nacional de Intoxicaciones HNN. (2017). Perfil epidemiológico de intoxicaciones en Costa Rica. San José, Costa Rica.
8. Galofre-Ruiz, M., Padilla-Castañeda, E. (2014). Intoxicación con rodenticidas: casos reportados al Centro de Información, Gestión e Investigación en Toxicología de la Universidad Nacional de Colombia. Revista Facultad Medicina, 62(1), 27-32.
9. Lee, H., You, M., Moon, W., Sul, H., Chung, C. Partk, C. y Park, S. (2014). Evaluation of risk factors in patients with vitamin K-dependent coagulopathy presumed to be caused by exposure to brodifacoum. Korean J Intern Med, 29, 498-508.
10. Park, J. (2014). Can we more efficiently save patients with vitamin K-dependent coagulopathy caused by superwarfarin intoxication? Korean J Intern Med, 29, 430-433.
11. Xiang, L., Min, Z., Alan, Z., y Yaohui, W. (2014). Retrospective Study of Twenty-Four Patients With Prolonged Coagulopathy Due to Long-Acting Anti-Vitamin K Rodenticide Poisoning. The American Journal of the Medical Sciences, 347(4), 299-304.
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