Obesity and cancer
Keywords:
Obesity, neoplasia, cancer.Abstract
Obesity is a disease with one of the highest incidence and prevalence worldwide, mainly due to unhealthy lifestyles such as sedentary lifestyle and Western diet. A body mass index >30.0 kg/m2 is the measure used to diagnose this condition. Although the relationship of obesity with type 2 diabetes mellitus and with cardiovascular disease is widely known, its association with cancer is not so much. Obesity has been implicated in the pathogenesis of malignant neoplasms of the esophagus, pancreas, colon, rectum, endometrium, kidney and breast in postmenopausal women. Chronic inflammation and insulin resistance are pathophysiological mechanisms that develop because of the consequence of obesity and provide an optimal environment for the acquisition of oncogenic mutations and tumor growth. Obesity produces changes in stem cells of the adipose tissue that result in tissue hypoxia and angiogenesis, thus facilitating a development of metastasis with greater ease and inadequate response to treatment as well.
References
2. Wagner M, Samdal Steinskog ES, Wiig H. Adipose tissue macrophages: the inflammatory link between obesity and cancer? Expert Opin Ther Targets. 2015;19(4):527-538.
3. Ligibel JA, Alfano CM, Courneya KS, Demark-Wahnefried W, Burger RA, Chlebowski RT, et al. American Society of Clinical Oncology Position Statement on Obesity and Cancer. J Clin Oncol. 2014;32(31):3568-3574.
4. Louie SM, Roberts LS, Nomura DK. Mechanisms Linking Obesity and Cancer. Biochim Biophys Acta. 2013;1831(10):1499-1508.
5. De Pergola G, Silvestris F. Obesity as a Major Risk Factor for Cancer. J Obes. 2013;2013:1-11.
6. Sánchez C, Ibáñez C, Klaassen J. Obesidad y cáncer: la tormenta perfecta. Rev Med Chil. 2014;142(2):211-221.
7. Lashinger LM, Ford NA, Hursting SD. Interacting Inflammatory and Growth Factor Signals Underlie the Obesity-Cancer Link. J Nutr. 2014;144(2):109-113.
8. Garg SK, Maurer H, Reed K, Selagamsetty R. Diabetes and cancer: two diseases with obesity as a common risk factor. Diabetes Obes Metab. 2014;16(2):97-110.
9. Shanmugalingam T, Crawley D, Bosco C, Melvin J, Rohrmann S, Chrowdhury S, et al. Obesity and cancer: the role of vitamin D. BMC Cancer. 2014 Sep 25;14:712
10. Berger NA. Obesity and cancer pathogenesis. Ann N Y Acad Sci. 2014;1311:57-76.
11. Sergeev IN. Vitamin D-mediated apoptosis in cancer and obesity. Horm Mol Biol Clin Investig. 2014;20(2):43-49.
12 . Xu M, Jung X, Hines J, Eibl G, Chen Y. Obesity and Pancreatic Cancer. Overview of Epidemiology and Potential Prevention by Weight Loss. Pancreas. 2018;47:158–162.
13. Lashinger LM, Rossi EL, Hursting SD. Obesity and Resistance to Cancer Chemotherapy: Interacting Roles of Inflammation and Metabolic Dysregulation. Clin Pharmacol Ther. 2014;96(4):458-46.
14. Ligibel JA, Strickler HD. Obesity and Its Impact on Breast Cancer: Tumor Incidence, Recurrence, Survival, and Possible Interventions. Am Soc Clin Oncol Educ Book. 2013:52-59.
15. Bardou M, Barkin AN, Martel M. Obesity and colorectal cancer. Gut. 2013;62(6):933-947.
16. Riondino S, Roselli M, Palmirotta R, Della-Morte D, Ferroni P, Guadagni F. Obesity and colorectal cancer: Role of adipokines in tumor initiation and progression.World J Gastroenterol. 201414;20(18):5177-5190
17. Arem H, Irwin ML. Obesity and endometrial cancer survival: a systematic review. Int J Obes. 2013;37(5):634-639.
18. Rogers CJ, Sandeep Prabhu K, Vijay-Kumar M.The Microbiome and Obesity—An Established Risk for Certain Types of Cancer. Cancer J. 2014;20(3):176–180.
Downloads
Published
Issue
Section
License
The intellectual property of accepted works belongs to their authors, however access to them is totally open and free, so they can be reproduced totally or partially with the only limitation of recognizing the authorship and the source of publication (Revista Medicina Legal de Costa Rica), as long as said exploitation does not have commercial character.
