Análisis de los efectos del consumo de alcohol en la morbi-mortalidad por trauma craneoencefálico
Palabras clave:
Trauma craneoencefálico, intoxicación por alcohol, apoptosis, caspasa, neuroprotección, receptor NDMA, etanol
Resumen
La intoxicación con alcohol está frecuentemente asociada con trauma craneoencefálico (TCE), pero el impacto del alcohol en la patogénesis y el pronóstico del TCE sigue siendo poco clara. La literatura actual provee evidencia en términos de datos clínicos y experimentales que respaldan los efectos neuroprotectores del alcohol en pacientes con TCE.
Para establecer de manera significativa esta relación es necesario el desarrollo de estudios prospectivos observacionales fuertes, con el fin de comprender los efectos del alcohol en los resultados clínicos a largo plazo (incluyendo el resultado neurológico) en pacientes con TCE con una apropiada selección y ajuste del riesgo basal.
Citas
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2. Langlois JA, Rutland-Brown W, Thomas KE. Traumatic brain injury in the United States; emergency department visits, hospitalizations, and deaths. 2006.
3. Thurman DJ, Alverson C, Dunn KA, Guerrero J, Sniezek JEJTJohtr. Traumatic brain injury in the United States: a public health perspective. 1999;14(6):602-15.
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11. Opreanu RC, Kuhn D, Basson MDJJotACoS. Influence of alcohol on mortality in traumatic brain injury. 2010;210(6):997-1007.
12. Lee J-M, Zipfel GJ, Choi DWJN. The changing landscape of ischaemic brain injury mechanisms. 1999;399(6738):A7.
13. Biegon A, Fry PA, Paden CM, Alexandrovich A, Tsenter J, Shohami EJPotNAoS. Dynamic changes in Nmethyl-D-aspartate receptors after closed head injury in mice: implications for treatment of neurological and cognitive deficits. 2004;101(14):5117-22.
14. Ikonomidou C, Turski LJTLN. Why did NMDA receptor antagonists fail clinical trials for stroke and traumatic brain injury? 2002;1(6):383-6.
15. Hamill RW, Woolf PD, McDonald JV, Lee LA, Kelly MJAoNOJotANA, Society tCN. Catecholamines predict outcome in traumatic brain injury. 1987;21(5):438-43.
16. Woolf PD, Cox C, Kelly M, McDonald JV, Hamill RWJAC, Research E. Alcohol intoxication blunts sympatho‐adrenal activation following brain injury. 1990;14(2):205-9.
17. Zink BJ, Schultz CH, Wang X, Mertz M, Stern SA, Betz ALJBr. Effects of ethanol on brain lactate in experimental traumatic brain injury with hemorrhagic shock. 1999;837(1-2):1-7.
18. Molina PE, Sulzer JK, Whitaker AJS. Alcohol abuse and the injured host; Dysregulation of counterregulatory mechanisms Review. 2013;39(3).
19. Chen CM, Yi H-Y, Yoon Y-H, Dong CJJosoa, drugs. Alcohol use at time of injury and survival following traumatic brain injury: results from the National Trauma Data Bank. 2012;73(4):531-41.
20. Chandrasekar A, olde Heuvel F, Wepler M, Rehman R, Palmer A, Catanese A, et al. The Neuroprotective Effect of Ethanol Intoxication in Traumatic Brain Injury Is Associated with the Suppression of ErbB Signaling in Parvalbumin-Positive Interneurons. 2018;35(22):2718-35.
21. Kanbak G, Kartkaya K, Ozcelik E, Guvenal AB, Kabay SC, Arslan G, et al. The neuroprotective effect of acute moderate alcohol consumption on caspase-3 mediated neuroapoptosis in traumatic brain injury: the role of lysosomal cathepsin L and nitric oxide. 2013;512(2):492-5.
22. Barker LH, Bigler ED, Johnson SC, Anderson CV, Russo AA, Boineau B, et al. Polysubstance abuse and traumatic brain injury: Quantitative magnetic resonance imaging and neuropsychological outcome in older adolescents and young adults. 1999;5(7):593-608.
23. Wilde EA, Bigler ED, Gandhi PV, Lowry CM, Blatter DD, Brooks J, et al. Alcohol abuse and traumatic brain injury: quantitative magnetic resonance imaging and neuropsychological outcome. 2004;21(2):137-47.
24. S. Tate P, David MF, Charles HB, Stephanie LH, Brinkman SJBI. Traumatic brain injury: influence of blood alcohol level on post-acute cognitive function. 1999;13(10):767-84.
25. Bombardier CH, Thurber CAJBi. Blood alcohol level and early cognitive status after traumatic brain injury. 1998;12(9):725-34.
26. Kelly MP, Johnson CT, Knoller N, Drubach DA, Winslow MMJBi. Substance abuse, traumatic brain injury and neuropsychological outcome. 1997;11(6):391-402.
27. Bigler ED, Blatter D, Johnson S, Anderson C, Russo A, Gale S, et al. Traumatic brain injury, alcohol and quantitative neuroimaging: preliminary findings. 1996;10(3):197-206.
28. Lange RT, Iverson GL, Franzen MDJN. Short-term neuropsychological outcome following uncomplicated mild TBI: Effects of day-of-injury intoxication and pre-injury alcohol abuse. 2007;21(5):590.
29. Vickery CD, Sherer M, Nick TG, Nakase-Richardson R, Corrigan JD, Hammond F, et al. Relationships among premorbid alcohol use, acute intoxication, and early functional status after traumatic brain injury. 2008;89(1):48-55.
30. PORTER RSJPec. Alcohol and injury in adolescents. 2000;16(5):316-20.
31. Hadjibashi AA, Berry C, Ley EJ, Bukur M, Mirocha J, Stolpner D, et al. Alcohol is associated with a lower pneumonia rate after traumatic brain injury. 2012;173(2):212-5.
32. Shahin H, Gopinath SP, Robertson CSJTJot. Influence of alcohol on early Glasgow Coma Scale in headinjured patients. 2010;69(5):1176.
33. Salim A, Ley EJ, Cryer HG, Margulies DR, Ramicone E, Tillou AJAoS. Positive serum ethanol level and mortality in moderate to severe traumatic brain injury. 2009;144(9):865-71.
34. Brennan JH, Bernard S, Cameron PA, Rosenfeld JV, Mitra BJJocn. Ethanol and isolated traumatic brain injury. 2015;22(9):1375-81.
2. Langlois JA, Rutland-Brown W, Thomas KE. Traumatic brain injury in the United States; emergency department visits, hospitalizations, and deaths. 2006.
3. Thurman DJ, Alverson C, Dunn KA, Guerrero J, Sniezek JEJTJohtr. Traumatic brain injury in the United States: a public health perspective. 1999;14(6):602-15.
4. Blincoe LJ, Seay AG, Zaloshnja E, Miller TR, Romano EO, Luchter S, et al. The economic impact of motor vehicle crashes, 2000. United States. National Highway Traffic Safety Administration; 2002.
5. Fabbri A, Marchesini G, Morselli-Labate A, Rossi F, Cicognani A, Dente M, et al. Positive blood alcohol concentration and road accidents. A prospective study in an Italian emergency department. 2002;19(3):210-4.
6. Corrigan JDJAopm, rehabilitation. Substance abuse as a mediating factor in outcome from traumatic brain injury. 1995;76(4):302-9.
7. Kolakowsky-Hayner Evgi, Jeffrey S. Kreutzer, Jennifer H. Marwitz, David X. Cifu, William O. Mckinley, Stephanie A. Brain Injury. Pre-injury substance abuse among persons with brain injury and persons with spinal cord injury. 1999;13(8):571-81.
8. Maas AI, Menon DK, Lingsma HF, Pineda JA, Sandel ME, Manley GTJJon. Re-orientation of clinical research in traumatic brain injury: report of an international workshop on comparative effectiveness research. 2012;29(1):32-46.
9. Maas A, Murray G, Roozenbeek B, Lingsma H, Butcher I, McHugh G, et al. International Mission on Prognosis Analysis of Clinical Trials in Traumatic Brain Injury (IMPACT) Study GroupAdvancing care for traumatic brain injury: findings from the IMPACT studies and perspectives on future research. 2013;12:1200-10.
10. KELLY DFJJon. Alcohol and head injury: an issue revisited. 1995;12(5):883-90.
11. Opreanu RC, Kuhn D, Basson MDJJotACoS. Influence of alcohol on mortality in traumatic brain injury. 2010;210(6):997-1007.
12. Lee J-M, Zipfel GJ, Choi DWJN. The changing landscape of ischaemic brain injury mechanisms. 1999;399(6738):A7.
13. Biegon A, Fry PA, Paden CM, Alexandrovich A, Tsenter J, Shohami EJPotNAoS. Dynamic changes in Nmethyl-D-aspartate receptors after closed head injury in mice: implications for treatment of neurological and cognitive deficits. 2004;101(14):5117-22.
14. Ikonomidou C, Turski LJTLN. Why did NMDA receptor antagonists fail clinical trials for stroke and traumatic brain injury? 2002;1(6):383-6.
15. Hamill RW, Woolf PD, McDonald JV, Lee LA, Kelly MJAoNOJotANA, Society tCN. Catecholamines predict outcome in traumatic brain injury. 1987;21(5):438-43.
16. Woolf PD, Cox C, Kelly M, McDonald JV, Hamill RWJAC, Research E. Alcohol intoxication blunts sympatho‐adrenal activation following brain injury. 1990;14(2):205-9.
17. Zink BJ, Schultz CH, Wang X, Mertz M, Stern SA, Betz ALJBr. Effects of ethanol on brain lactate in experimental traumatic brain injury with hemorrhagic shock. 1999;837(1-2):1-7.
18. Molina PE, Sulzer JK, Whitaker AJS. Alcohol abuse and the injured host; Dysregulation of counterregulatory mechanisms Review. 2013;39(3).
19. Chen CM, Yi H-Y, Yoon Y-H, Dong CJJosoa, drugs. Alcohol use at time of injury and survival following traumatic brain injury: results from the National Trauma Data Bank. 2012;73(4):531-41.
20. Chandrasekar A, olde Heuvel F, Wepler M, Rehman R, Palmer A, Catanese A, et al. The Neuroprotective Effect of Ethanol Intoxication in Traumatic Brain Injury Is Associated with the Suppression of ErbB Signaling in Parvalbumin-Positive Interneurons. 2018;35(22):2718-35.
21. Kanbak G, Kartkaya K, Ozcelik E, Guvenal AB, Kabay SC, Arslan G, et al. The neuroprotective effect of acute moderate alcohol consumption on caspase-3 mediated neuroapoptosis in traumatic brain injury: the role of lysosomal cathepsin L and nitric oxide. 2013;512(2):492-5.
22. Barker LH, Bigler ED, Johnson SC, Anderson CV, Russo AA, Boineau B, et al. Polysubstance abuse and traumatic brain injury: Quantitative magnetic resonance imaging and neuropsychological outcome in older adolescents and young adults. 1999;5(7):593-608.
23. Wilde EA, Bigler ED, Gandhi PV, Lowry CM, Blatter DD, Brooks J, et al. Alcohol abuse and traumatic brain injury: quantitative magnetic resonance imaging and neuropsychological outcome. 2004;21(2):137-47.
24. S. Tate P, David MF, Charles HB, Stephanie LH, Brinkman SJBI. Traumatic brain injury: influence of blood alcohol level on post-acute cognitive function. 1999;13(10):767-84.
25. Bombardier CH, Thurber CAJBi. Blood alcohol level and early cognitive status after traumatic brain injury. 1998;12(9):725-34.
26. Kelly MP, Johnson CT, Knoller N, Drubach DA, Winslow MMJBi. Substance abuse, traumatic brain injury and neuropsychological outcome. 1997;11(6):391-402.
27. Bigler ED, Blatter D, Johnson S, Anderson C, Russo A, Gale S, et al. Traumatic brain injury, alcohol and quantitative neuroimaging: preliminary findings. 1996;10(3):197-206.
28. Lange RT, Iverson GL, Franzen MDJN. Short-term neuropsychological outcome following uncomplicated mild TBI: Effects of day-of-injury intoxication and pre-injury alcohol abuse. 2007;21(5):590.
29. Vickery CD, Sherer M, Nick TG, Nakase-Richardson R, Corrigan JD, Hammond F, et al. Relationships among premorbid alcohol use, acute intoxication, and early functional status after traumatic brain injury. 2008;89(1):48-55.
30. PORTER RSJPec. Alcohol and injury in adolescents. 2000;16(5):316-20.
31. Hadjibashi AA, Berry C, Ley EJ, Bukur M, Mirocha J, Stolpner D, et al. Alcohol is associated with a lower pneumonia rate after traumatic brain injury. 2012;173(2):212-5.
32. Shahin H, Gopinath SP, Robertson CSJTJot. Influence of alcohol on early Glasgow Coma Scale in headinjured patients. 2010;69(5):1176.
33. Salim A, Ley EJ, Cryer HG, Margulies DR, Ramicone E, Tillou AJAoS. Positive serum ethanol level and mortality in moderate to severe traumatic brain injury. 2009;144(9):865-71.
34. Brennan JH, Bernard S, Cameron PA, Rosenfeld JV, Mitra BJJocn. Ethanol and isolated traumatic brain injury. 2015;22(9):1375-81.
Publicado
2020-11-16
Cómo citar
Pacheco Figueroa, C. (2020). Análisis de los efectos del consumo de alcohol en la morbi-mortalidad por trauma craneoencefálico. Medicina Legal De Costa Rica, 37(1). Recuperado a partir de //www.binasss.sa.cr/ojssalud/index.php/mlcr/article/view/145
Sección
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